Filed Under (Skin Care) by David on 09-02-2010
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In October, the FDA stated that it had received 30 reports of acute pancreatitis in patients taking exenatide (Byetta, Amlyn Pharmaceuticals) for the treatment of type-2 diabetes. Of 30 patients, 27 had at least one other risk factor for acute pancreatitis such as gallstones, severe hypertriglyceridemia, or alcohol use.
In six patients, the pancreatitis symptoms began or worsened soon after the dose of exenatide was increased from 5 mcg twice daily to 10 mcg twice daily. Twenty-one patients were hospitalized.
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Filed Under (Skin Care) by David on 16-01-2010
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Roche has discontinued the manufacture and distribution of isotretinoin (Accutane drags, Roche), a medication for severe acne, in the U.S. The company said that the withdrawal was based on business reasons. Isotretinoin will continue to be available as a generic agent.
First developed as a chemotherapy agent, the capsules were approved in 1982 and became Roche’s second-largest selling drug before its patent expired in 2002 and other companies began marketing generic versions.
Sources: Bloomberg News, June 26, 2009
Filed Under (Skin Care) by David on 08-01-2010
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Adding unfractionated heparin (UFH) to standard therapy with enoxaparin (Lovenox, Sanofi-Aventis) may lead to excessive anticoagulation and should be avoided, according to the STACKENOX (Stack-on to Enoxaparin) study. An additional intravenous (IV) bolus of UFH resulted in complete inhibition of thrombin generation, even when it was given up to 10 hours after the last enoxaparin dose. Moreover, tests commonly used to monitor UFH anticoagulation, such as activated clotting time (ACT), do not detect the potential overanticoagulation that results from the stack-on therapy.
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Filed Under (Skin Care) by David on 06-01-2010
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Protalix BioTherapeutics, Inc., has announced the approval of a protocol for prGCD, a proprietary plant-cell expressed recombinant form of glucocerebrosidase (GCD) for the treatment of patients with Gaucher disease. This rare and serious lysosomal storage disorder is characterized by debilitating symptoms.
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