Filed Under (Skin Care) by David on 16-01-2010
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Roche has discontinued the manufacture and distribution of isotretinoin (Accutane drags, Roche), a medication for severe acne, in the U.S. The company said that the withdrawal was based on business reasons. Isotretinoin will continue to be available as a generic agent.
First developed as a chemotherapy agent, the capsules were approved in 1982 and became Roche’s second-largest selling drug before its patent expired in 2002 and other companies began marketing generic versions.
Sources: Bloomberg News, June 26, 2009
Filed Under (Skin Care) by David on 08-01-2010
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Adding unfractionated heparin (UFH) to standard therapy with enoxaparin (Lovenox, Sanofi-Aventis) may lead to excessive anticoagulation and should be avoided, according to the STACKENOX (Stack-on to Enoxaparin) study. An additional intravenous (IV) bolus of UFH resulted in complete inhibition of thrombin generation, even when it was given up to 10 hours after the last enoxaparin dose. Moreover, tests commonly used to monitor UFH anticoagulation, such as activated clotting time (ACT), do not detect the potential overanticoagulation that results from the stack-on therapy.
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